by Miroslav Djordjevic and Francisko Martins
English | 2016 | ISBN: 1634852710 | 456 Pages | PDF | 11 MB
Erectile dysfunction is a common problem that can severely impact the quality of life for both patient and his partner. Understanding and management of erectile dysfunction have evolved significantly over the last decades. Recent advances and breakthroughs in our knowledge of the vascular mechanisms responsible for the physiology of penile erection have led to the critical recognition of erectile dysfunction as a premature manifestation of cardiovascular disease. Screening for major health concerns, such as atherosclerosis, hyperlipidemia, hypertension, diabetes mellitus and other metabolic diseases has become an integral part of the evaluation of erectile dysfunction. Extensive research on mechanisms involved in the regulation of penile erection has led to great advances in the understanding of general vascular regulation. However, there are still many unknowns, opening vast opportunities for basic science and clinical research in the future.
The estimated incidence and prevalence of ED worldwide has not been clearly defined and varies greatly with country and age. However, all age groups of men seem to be affected. Despite persisting taboos surrounding ED, more men are seeking professional help and treatment. The advent of novel treatment options in recent years, most notably oral PDE-5 inhibitors, has shined a new light on the primary vascular cause and treatment target in some cases. Several new oral medications for ED have been introduced and others are emerging on the horizon.
The International Book of Erectile Dysfunction is a comprehensive overview of male sexual dysfunction in its different aspects. It discusses pathophysiology of ED, approaches to diagnostic evaluation and therapeutic options, including specificities of ED in men with chronic diseases, such as diabetes mellitus, hypertension, coronary artery disease, heart failure, chronic kidney disease and transplantation, LUTS/BPH, spinal cord injury, endocrine problems, as well as some relatively unexplored conditions such as erectile (dys)function in female-to-male transsexuals and penile cancer survivors. All viewpoints described in this book regarding the various topics of ED, namely pathophysiology and risk factors, current diagnostic algorithm in the era of efficacious oral pharmacotherapy, interventional and surgical therapies, as well as new minimally invasive treatment modalities are based on published literature and ongoing research trials, and enriched and “seasoned” by an international perspective provided by experts in the field of ED from different corners of the world.
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